Category: Parkinson’s News

The Brainerd Lakes Area Parkinson’s Disease Support Group meeting will be at 1 p.m. Thursday, Feb. 1, at Lord of Life Church.

Bridging the divide between Parkinson scientists and the Parkinson community

Vesper Bio has announced that they have been awarded a grant worth $873,000 by The Michael J. Fox Foundation for Parkinson’s Research (MJFF) to assess sortilin inhibition in Parkinson’s disease.

The former England spinner was diagnosed with Parkinson’s in 2019.

Eleven years ago, when I first reported that I was diagnosed by several doctors with Parkinson’s disease, I thought I knew then much about this neurodegenerative condition for which there

Early detection, regular medication and exercises are necessary for Parkinson’s patients to manage their motor functions. But above all you need a positive spirit, says Dr Rajas Deshpande, Director of Neurology, Jupiter Hospital, Pune

Parkinson’s Disease (PD) is the second most common neurodegenerative disorder. The pathological hallmark of PD is loss of dopaminergic neurons and the presence of aggregated α-synuclein, primarily in the substantia nigra pars compacta (SNpc) of the midbrain. However, the molecular mechanisms that underlie the pathology in different cell types is not currently understood. Here, we present a single nucleus transcriptome analysis of human post-mortem SNpc obtained from 15 sporadic Parkinson’s Disease (PD) cases and 14 Controls. Our dataset comprises ∼84K nuclei, representing all major cell types of the brain, allowing us to obtain a transcriptome-level characterization of these cell types. Importantly, we identify multiple subpopulations for each cell type and describe specific gene sets that provide insights into the differing roles of these subpopulations. Our findings reveal a significant decrease in neuronal cells in PD samples, accompanied by an increase in glial cells and T cells. Subpopulation analyses demonstrate a significant depletion of tyrosine hydroxylase (TH) enriched astrocyte, microglia and oligodendrocyte populations in PD samples, as well as TH enriched neurons, which are also depleted. Moreover, marker gene analysis of the depleted subpopulations identified 28 overlapping genes, including those associated with dopamine metabolism (e.g., ALDH1A1, SLC6A3 & SLC18A2). Overall, our study provides a valuable resource for understanding the molecular mechanisms involved in dopaminergic neuron degeneration and glial responses in PD, highlighting the existence of novel subpopulations and cell type-specific gene sets.

A new paper elaborates on how and why microglia fail to clean up the α-synuclein protein of Parkinson’s disease, gradually making the disease worse. The aggregation of Parkinson’s Parkinson’s disease, like Alzheimer’s, is characterized by protein aggregation. […]

The following is a summary of “Factor analysis for construct validity of a trunk impairment scale in Parkinson’s disease: a cross-sectional study,”…